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What is Juxtaglomerular cell tumor?
Juxtaglomerular cell tumor (JGCT), also known as reninoma, is an extremely rare kidney tumor of the juxtaglomerular cells that typically secrete renin. It often causes severe hypertension that is difficult to control in young adults.
What is a reninoma?
Reninomas are benign tumors originating from the cells of the juxtaglomerular apparatus. They produce excessive amounts of renin, leading to secondary hyperaldosteronism. As a consequence of this hormonal activation, patients develop severe hypertension, potassium wasting, and hypokalemia.
What do juxtaglomerular cells release?
renin
The juxtaglomerular cells secrete renin, and as specialised smooth muscle cells surrounding the afferent arteriole also have the capacity to affect the perfusion of the glomerulus.
Where are juxtaglomerular cells located?
Juxtaglomerular cells (JG cells), also known as granular cells are cells in the kidney that synthesize, store, and secrete the enzyme renin. They are specialized smooth muscle cells mainly in the walls of the afferent arterioles (and some in the efferent arterioles) that deliver blood to the glomerulus.
How is Reninoma diagnosed?
Diagnostic imaging is employed to identify the source of excessive renin production. While renal ultrasound can miss reninoma, contrast CT or magnetic resonance imaging of the kidneys are diagnostic modalities of choice leading to the correct diagnosis.
Is Wilms tumor common?
Make an appointment with your child’s doctor if you notice any signs or symptoms that worry you. Wilms’ tumor is rare, so it’s much more likely that something else is causing symptoms, but it’s important to check out any concerns.
How is Reninoma treated?
Surgical resection is the major treatment modality for reninoma, because of its benign course; only 1 case was reported as recurred after initial mass resection [3,4]. JCT can be treated with a nephron-sparing partial nephrectomy (as was performed in our patient) because these tumors are usually superficially located.
Which hormone is secreted by juxtaglomerular cells?
Renin
Renin is a hormone secreted by the juxtaglomerular cells of the kidney; it interacts with a plasma protein substrate to produce a decapeptide prohormone angiotensin I.
What do juxtaglomerular cells secrete?
The juxtaglomerular cells secrete renin, and as specialised smooth muscle cells surrounding the afferent arteriole also have the capacity to affect the perfusion of the glomerulus.
What is juxtaglomerular?
The juxtaglomerular apparatus is the location of renin-secreting cells and the macula densa and lies at the junction between the loop of Henle and the distal nephron at which the tubule comes in close proximity to the afferent arteriole.16.
Can Wilms tumor be cured?
Wilms tumour is curable in more than 9 out of 10 children (90%). The main treatments include: chemotherapy for almost all children. surgery for all children.
How long can you live with Wilms tumor?
Survival rates for Wilms tumors
| Wilms Tumor 4-year Survival Rates | ||
|---|---|---|
| Tumor Stage | Favorable Histology | Diffuse Anaplastic |
| II | 95% – 100% | 80% – 85% |
| III | 95% – 100% | 50% – 70% |
| IV | 85% – 90% | 30% – 45% |
How can I reduce my angiotensin 2 naturally?
Fish, poultry, starchy vegetables, and most types of fruit can contain vitamin B6. A 2014 study states that vitamin B6 may mimic the effects of hypertension medications such as diuretics, calcium-channel blockers, and central alpha agonists. Vitamin B6 may also block angiotensin receptors and widen blood vessels.
Why is renin released?
Renin is released into your bloodstream when your blood pressure drops too low or when there’s not enough sodium in your body. Specifically, renin secretion happens when: Baroreceptors (pressure-sensitive receptors) in your arterial vessels detect low blood pressure. Your kidneys detect low salt (sodium) levels.
When do JG cells release renin?
fall in blood pressure
Juxtaglomerular Cells Baroreceptors found in the arterioles trigger renin secretion if there is a fall in blood pressure in the arterioles. Activation of the sympathetic nervous system can also stimulate renin release through activation of beta-1 receptors.
What is the function of JGA?
The JGA regulates renal hemodynamics through the mechanism of tubuloglomerular feedback (TGF), whereby variations in tubular fluid flow and composition in the cortical thick ascending limb are detected by the macula densa cells, and trigger changes in afferent arteriole diameter and renin secretion in response (see …