How does temozolomide work?

How does temozolomide work?

Temozolomide works by stopping cancer cells from making DNA. DNA stands for DeoxyriboNucleic Acid. It is the genetic material of a cell. If the cancer cells can’t make DNA, they can’t split into 2 new cells, so the cancer can’t grow.

Is temozolomide polar?

Temozolomide is an orally administered alkylating agent used largely in the therapy of malignant brain tumors including glioblastoma and astrocytoma….3.1Computed Properties.

How does Temozolomide target cancer cells?

Summary. Temozolomide is a monofunctional alkylating agent with established utility in the treatment of malignant glioma. This chemotherapy induces cytotoxic damage through the creation of methyl adducts at the O6 position on the DNA base guanine.

What is the half life of temozolomide?

Administration and Effects The half-life of temozolomide is approximately 1.8 hours, with the active half-life of the metabolite (MTIC) being slightly longer. Temozolomide and its metabolites are excreted via the kidneys.

What type of drug is temozolomide?

It belongs to the group of medicines known as antineoplastics (cancer medicines). Temozolomide interferes with the growth of cancer cells, which are then destroyed by the body.

Who manufactures temozolomide?

In late 2019, Merck, a pharmaceutical company that manufactures Temodar (the brand name version of the drug), decided to remove the drug from its patient prescription assistance program (PAP).

How is temozolomide metabolized?

After absorption, temozolomide undergoes nonenzymatic chemical conversion to the active metabolite 5-(3-methyltriazen-1-yl) imidazole-4-carboxamide (MTIC) plus carbon dioxide and to a temozolomide acid metabolite, which occurs at physiological pH but is enhanced with increasing alkalinity.

Who developed temozolomide?

TMZ was developed at Aston University (Birmingham, UK) more than 20 years ago. In 1999, the US Food and Drug Administration granted approval to Merck to market it under the trade name Temodar for treating glioblastoma and refractory anaplastic astrocytoma.

When was temozolomide invented?

Temozolomide was first licensed in 1999, initially as a second- line treatment for glioblastoma multiforme, the most malignant grade of glioma. The indications for which it can be prescribed have been increasing since, along with its sales.

Who is the manufacturer for Temodar?

When was temozolomide first developed?

Where was temozolomide discovered?

Temozolomide was first produced in the relatively small quantities needed for lab work at Aston University.

What is the generic for Temodar?

Mylan’s temozolomide capsules will come in 5 mg, 20 mg, 100 mg, 140 mg, 180 mg, and 250 mg dosage forms. The manufacturer announced the approval of its abbreviated new drug application on July 11, 2016.

Who is the manufacturer of temozolomide?

Teva Pharmaceutical Industries Ltd. (NYSE: TEVA) and Perrigo Company (NYSE: PRGO;TASE) today announced the launch of the generic equivalent to Temodar® (temozolomide)….Cookie Settings.

How much does Temozolomide cost?

TEMOZOLOMIDE is a chemotherapy drug. It is used to treat some kinds of brain cancer. The lowest GoodRx price for the most common version of temozolomide is around $54.77, 97% off the average retail price of $2,422.13.

Is there a generic for Temodar?

Mylan has launched a generic version of Merck’s Temodar capsules, which may be used to treat patients with newly diagnosed cancerous tumors known as glioblastoma multiforme concomitantly with radiotherapy, then as maintenance treatment.

Is there a generic for temozolomide?

Temodar is the trade name for temozolomide. In some cases, health care professionals may use the trade name temodar when referring to the generic drug name temozolomide. Drug type: Temozolomide is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug.

What is the mechanism of resistance to temozolomide?

Two mechanisms of resistance to temozolomide effects have now been described: 1) intrinsic resistance conferred by MGMT deficiency (MGMTd) and 2) intrinsic or acquired resistance through MMR deficiency (MMRd). The MGMT enzyme is the first line of repair of mismatched bases created by TMZ.

What is temozolomide?

Temozolomide is an imidazotetrazine derivative. It is slightly soluble in water and aqueous acids, and decomposes at 212 °C (414 °F). It was recently discovered that temozolomide is an explosive, tentatively assigned as UN Class 1. The agent was developed by Malcolm Stevens and his team at Aston University in Birmingham, England.

How is temozolomide absorbed from the gut?

Temozolomide is quickly and almost completely absorbed from the gut, and readily penetrates the blood–brain barrier; the concentration in the cerebrospinal fluid is 30% of the concentration in the blood plasma. Intake with food decreases maximal plasma concentrations by 33% and the area under the curve by 9%.

What is the half life of temozolomide acid?

Other metabolites include temozolomide acid and unidentified hydrophilic substances. Plasma half-life is 1.8 hours. The substance and its metabolites are mainly excreted via the urine. Temozolomide is an imidazotetrazine derivative. It is slightly soluble in water and aqueous acids, and decomposes at 212 °C (414 °F).