Table of Contents
What is SCC larynx?
Squamous cell carcinoma of the larynx is the most common primary malignant tumour that affects the laryngeal framework. Typically it is categorised by the laryngeal subsite affected, which affects presentation, treatment and prognosis.
What is Glottic SCC?
Glottic cancer is a malignancy of the larynx that involves the true vocal cords and anterior and posterior commissures. Because of its anatomic location, it can have profound effects on the basic vital functions, including breathing, swallowing, voice, and, ultimately, mortality.
What does Transglottic mean?
trans·glot·tic (trans-glot’ik), Vertical crossing of the glottis, as in the spread of carcinoma from the supraglottic to the infraglottic area.
What is Stage 3 larynx cancer?
Stage 3 laryngeal cancer has grown throughout the larynx but has not spread to other parts of the body. OR at least one vocal cord is fixed and can’t move. OR the cancer may also have spread to a nearby lymph node, which is no larger than 3cm across.
Which type of carcinoma of the larynx has the best prognosis?
Glottic cancers have the best 5‐year relative survival rate, 77%, due to a higher percentage of patients presenting with localized disease (83%). Patients with subglottic primary tumors have a 5‐year relative survival rate of 53%.
What is glottic closure?
Reflex glottic closure is a dominant and stable reflex produced by stimulation of the superior laryngeal nerve. Its precise execution is basic to successful sphincteric protection of the lower airway. In exaggerated form, it produces life-threatening laryngospasm.
What is Transglottic mass?
Transglottic cancer of the larynx crosses the laryngeal ventricle and involves both the vestibular and vocal folds. It has been described to spread within the paraglottic space (PGS).
Can larynx cancer be cured?
Generally, early laryngeal cancer has a better cure rate. Advanced cancer that spreads to other areas has a poorer survival rate. But even advanced laryngeal cancer can be cured. If it comes back, it usually happens within the first two or three years after treatment.
How long after radiation does the mucus stop?
Mucositis caused by radiation therapy usually lasts 6 to 8 weeks, depending on how long the treatment was. In patients receiving high-dose chemotherapy or chemoradiation for stem cell transplant: Mucositis usually begins 7 to 10 days after treatment begins, and lasts for about 2 weeks after treatment ends.
What is a glottic gap?
Glottic insufficiency, also known as vocal fold insufficiency, occurs when your vocal cords cannot close completely. This will result in a gap between the folds so air can escape and vibrations do not occur.
What is glottic efficiency?
The ability to close (adduct) the vocal folds efficiently and easily – and to vibrate them strongly through rapid opening and closing cycles – is referred to as glottic efficiency.
What is glottic gap?
Glottal gaps are permanent or transient, partial, or total insufficiencies on the membranous or cartilaginous portion of the glottis during phonation. Glottal gaps can be either physiological or pathological. The latter are multifactorial, predominantly organic in origin and often functional.
What is Paraglottic space?
Background Paraglottic space (PGS) is a connective tissue compartment of the larynx and is important in the extension of laryngeal cancer. It communicates with the preepiglottic space superiorly and with the extralaryngeal region inferiorly through the gap within the cricothyroid membrane.
What is Postcricoid?
The postcricoid region is a subsite of the hypopharynx, comprising the anterior wall. The area includes the mucosa, intramural fat, and a rich venous plexus 1-3.
What does TNM mean?
The abbreviation “TNM” stands for tumor (T), nodes (N), and metastases (M). “Nodes” indicates whether or not the tumor has spread into neighboring (regional) lymph nodes.
What is the optimum treatment for t3n0 cancer larynx?
Controversy surrounds the optimum treatment of T3N0 cancer larynx. Curative radiotherapy with salvage surgery in reserve is an accepted methodology as is also a combined protocol of surgery and radiotherapy.
What is the staging system for larynx cancer?
The staging system most often used for laryngeal cancer is the American Joint Committee on Cancer (AJCC) TNM system, which is based on 3 key pieces of information: The extent of the main tumor (T): Where is the tumor? How far has it grown into the larynx and nearby structures?
What is the clinical stage of larynx cancer?
Laryngeal cancer is typically given a clinical stage based on the results of any exams, biopsies, and imaging tests that might have been done (as described in Tests for Laryngeal and Hypopharyngeal Cancers. If surgery has been done, the pathologic stage (also called the surgical stage) can be determined.
Is radiotherapy effective for organ preservation in advanced laryngeal cancer?
Importance: Radiotherapy (RT)-based organ preservation approaches for patients with advanced laryngeal cancer have been established stepwise through prospective randomized clinical trials.